Systemic Lupus Erythematosus (SLE) is an autoimmune disease (a disease in which the body starts attacking itself) that can progress to a serious multi-systemic disease. Left untreated, SLE can do serious damage to many of your dog’s vital systems, and may even result in death.

The most visible symptom of SLE will be lameness that seems to travel from one part of your dog's body to another. Muscle pain, arthritis, skin sores, blisters and fever usually follow. In fact, most dogs who end up having SLE are brought to the vet because they are exhibiting signs of lameness together with skin problems. Other symptoms that are observed less often include swollen lymph nodes, mouth ulcers, dementia and seizures. Some of the signs are similar to the symptoms experienced if your dog has immune-mediated hemolytic anemia or thrombocytopenia.

SLE seems to be manifested more frequently in certain breeds of dogs than in others. These breeds include Afghan Hounds, German Shepherds,  Old English Sheepdogs, Miniature Poodles, and Shetland Sheepdogs. The disease usually impacts middle aged-dogs of both sexes.

It is unclear exactly how SLE is contracted, but evidence shows that environmental factors may play a role along with possible hereditary predisposition.

Clinical signs, urine tests, blood tests, including a blood test referred to as an ANA (Anti-Nuclear Antibody titer) are required to diagnose SLE.

SLE can be treated with several medications. Treatment is aimed at decreasing the inflammation and autoimmune activity, and usually includes anti-inflammatory and immunosuppressive medications such as corticosteroids. Problems sometimes associated with SLE, such as specific organ damage, will also have to be treated accordingly.

The UV rays in natural sunlight can cause SLE to flare-up, so exposure to sunlight should be limited.

It is not known how to prevent SLE.

No, you cannot contract SLE from your dog.